Gene

rel

ID

ZDB-GENE-040718-255

Name

v-rel avian reticuloendotheliosis viral oncogene homolog

Symbol

rel Nomenclature History

Previous Names

c-rel (1)
zgc:100833 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Involved in brain development. Predicted to localize to I-kappaB/NF-kappaB complex; cytosol; and nucleoplasm. Is expressed in intestine. Orthologous to human REL (REL proto-oncogene, NF-kB subunit).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Bagheri et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rel Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 92	619652

Associated With rel Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030492	Rel homology domain, conserved site
Domain	IPR002909	IPT domain
Domain	IPR011539	Rel homology domain, DNA-binding domain
Domain	IPR032397	Rel homology dimerisation domain
Domain	IPR033926	NFkappaB IPT domain
Domain	IPR042845	Proto-oncogene c-Rel, RHD, N-terminal subdomain
Family	IPR000451	NF-kappa-B/Dorsal
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily