Gene
cmtm4
- ID
- ZDB-GENE-040718-195
- Name
- CKLF-like MARVEL transmembrane domain containing 4
- Symbol
- cmtm4 Nomenclature History
- Previous Names
-
- zgc:92853
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be active in membrane. Orthologous to human CMTM4 (CKLF like MARVEL transmembrane domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92853 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Chrifi et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cmtm4 | Bona et al., 2022 | |
| MO1-cmtm4 | N/A | Chrifi et al., 2018 |
| MO2-cmtm4 | N/A | Chrifi et al., 2018 |
| MO3-cmtm4 | N/A | Bona et al., 2022 |
| MO4-cmtm4 | N/A | Bona et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Marvel domain | MARVEL domain-containing and chemokine-like factor proteins |
|---|---|---|---|
|
UniProtKB:Q6DGM6
|
208 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-56M19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92853 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173834 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002492 (1) | 1468 nt | ||
| Genomic | GenBank:BX511128 (1) | 112766 nt | ||
| Polypeptide | UniProtKB:Q6DGM6 (1) | 208 aa |
- Bona, A., Seifert, M., Thünauer, R., Zodel, K., Frew, I.J., Römer, W., Walz, G., Yakulov, T.A. (2022) MARVEL-domain containing CMTM4 affects CXCR4 trafficking. Molecular biology of the cell. 33(13):ar116
- Chrifi, I., Louzao-Martinez, L., Brandt, M.M., van Dijk, C.G.M., Bürgisser, P.E., Zhu, C., Kros, J.M., Verhaar, M.C., Duncker, D.J., Cheng, C. (2018) CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions. Angiogenesis. 22(1):75-93
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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