Gene

dlg4b

ID
ZDB-GENE-040628-3
Name
discs, large homolog 4b (Drosophila)
Symbol
dlg4b Nomenclature History
Previous Names
  • dlg4
  • PSD95/SAP90 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Predicted to be involved in several processes, including chemical synaptic transmission; receptor clustering; and receptor localization to synapse. Localizes to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Is expressed in nervous system and neural tube. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Meyer et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlg4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder, autosomal dominant 62 618793
Associated With dlg4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020590 Guanylate kinase, conserved site
Domain IPR001452 SH3 domain
Domain IPR001478 PDZ domain
Domain IPR004172 L27 domain
Domain IPR008144 Guanylate kinase-like domain
Domain IPR008145 Guanylate kinase/L-type calcium channel beta subunit
Domain IPR015143 L27-1
Domain IPR019583 Disks large homolog 1-4, PDZ-associated domain
Domain IPR019590 Disks large homologue 1, N-terminal PEST domain
Family IPR016313 Disks large 1-like
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036892 L27 domain superfamily
Domain Details Per Protein
Protein Length Disks large 1-like Disks large homolog 1-4, PDZ-associated domain Disks large homologue 1, N-terminal PEST domain Guanylate kinase, conserved site Guanylate kinase-like domain Guanylate kinase/L-type calcium channel beta subunit L27-1 L27 domain L27 domain superfamily PDZ domain PDZ superfamily P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily
UniProtKB:Q6R005 801
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations