Gene
rbm24a
- ID
- ZDB-GENE-040628-1
- Name
- RNA binding motif protein 24a
- Symbol
- rbm24a Nomenclature History
- Previous Names
-
- rbm24
- seb-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables RNA binding activity. Involved in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening and positive regulation of sarcomere organization. Acts upstream of or within several processes, including embryonic organ morphogenesis; epithelial cell differentiation; and striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; cephalic musculature; immature eye; segmental plate; and sensory system. Used to study cataract and microphthalmia. Orthologous to human RBM24 (RNA binding motif protein 24).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sdu28 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | WT + MO6-rbm24a | standard conditions | Brastrom et al., 2019 |
| microphthalmia | WT + MO6-rbm24a | standard conditions | Brastrom et al., 2019 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA-binding_regulatory_proteins | RNA recognition motif domain |
|---|---|---|---|---|---|
|
UniProtKB:B3DI77
|
230 | ||||
|
UniProtKB:Q76LC6
|
230 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rbm24a-201
(1)
|
Ensembl | 664 nt | ||
| mRNA |
rbm24a-202
(1)
|
Ensembl | 3,029 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cryaa:rbm24a_delRRM-GFP) |
|
| 1 | Shao et al., 2020 | |
| Tg(myl7:rbm24a-2A-GFP) |
| 1 | Shao et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-108K24 | ||
| Contained in | Fosmid | CH1073-175O15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194503 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194514 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212865 (1) | 693 nt | ||
| Genomic | GenBank:CU856207 (2) | 55047 nt | ||
| Polypeptide | UniProtKB:B3DI77 (1) | 230 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Brastrom, L.K., Scott, C.A., Wang, K., Slusarski, D.C. (2021) Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia. Biomedicines. 9(2):
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Cheng, X.N., Zhang, J.J., Shi, D.L. (2020) Loss of Rbm24a causes defective hair cell development in the zebrafish inner ear and neuromasts. Journal of genetics and genomics = Yi chuan xue bao. 47(7):403-406
- Shao, M., Lu, T., Zhang, C., Zhang, Y.Z., Kong, S.H., Shi, D.L. (2020) Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation. Proceedings of the National Academy of Sciences of the United States of America. 117:7245-7254
- Zhang, Y., Wang, Y., Yao, X., Wang, C., Chen, F., Liu, D., Shao, M., Xu, Z. (2020) Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Frontiers in cell and developmental biology. 8:604026
- Brastrom, L.K., Scott, C.A., Dawson, D.V., Slusarski, D.C. (2019) A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 7(2)
- Dash, S., Brastrom, L.K., Patel, S.D., Scott, C.A., Slusarski, D.C., Lachke, S.A. (2019) The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Human molecular genetics. 29(4):591-604
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Maragh, S., Miller, R.A., Bessling, S.L., Wang, G., Hook, P.W., McCallion, A.S. (2014) Rbm24a and Rbm24b Are Required for Normal Somitogenesis. PLoS One. 9:e105460
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