ZFIN is now using GRCz12tu for Genomic Data
Gene
sms
- ID
- ZDB-GENE-040625-150
- Name
- spermine synthase
- Symbol
- sms Nomenclature History
- Previous Names
-
- zgc:86583
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable spermine synthase activity. Acts upstream of or within spermine biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in anxiety disorder and syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Keightley et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Frohnhöfer et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked intellectual disability Snyder type | Alliance | Intellectual developmental disorder, X-linked syndromic, Snyder-Robinson type | 309583 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030373 | Polyamine biosynthesis domain, conserved site |
| Domain | IPR030374 | Polyamine biosynthesis domain |
| Domain | IPR035246 | Spermidine synthase, tetramerisation domain |
| Domain | IPR040900 | Spermine synthase, N-terminal |
| Family | IPR015576 | Spermine synthase, animal |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR037163 | Spermidine synthase, tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Polyamine biosynthesis domain | Polyamine biosynthesis domain, conserved site | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Spermidine synthase, tetramerisation domain | Spermidine synthase, tetramerisation domain superfamily | Spermine synthase, animal | Spermine synthase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9YGC9 | InterPro | 360 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers