Gene
top1mt
- ID
- ZDB-GENE-040624-2
- Name
- DNA topoisomerase I mitochondrial
- Symbol
- top1mt Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; DNA topoisomerase type I (single strand cut, ATP-independent) activity; and FFAT motif binding activity. Predicted to be involved in DNA topological change and protein localization to endoplasmic reticulum. Predicted to localize to chromosome and endoplasmic reticulum membrane. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111830 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018521 | DNA topoisomerase I, active site |
| Domain | IPR008336 | DNA topoisomerase I, DNA binding, eukaryotic-type |
| Domain | IPR013499 | DNA topoisomerase I, eukaryotic-type |
| Domain | IPR013500 | DNA topoisomerase I, catalytic core, eukaryotic-type |
| Domain | IPR025834 | Topoisomerase I C-terminal domain |
| Domain | IPR048045 | DNA topoisomerase I, DNA-binding domain |
| Family | IPR001631 | DNA topoisomerase I |
| Family | IPR051062 | DNA topoisomerase IB |
| Homologous_superfamily | IPR011010 | DNA breaking-rejoining enzyme, catalytic core |
| Homologous_superfamily | IPR013030 | DNA topoisomerase I, DNA binding, N-terminal domain 2 |
| Homologous_superfamily | IPR013034 | DNA topoisomerase I, DNA binding, N-terminal domain 1 |
| Homologous_superfamily | IPR014711 | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type |
| Homologous_superfamily | IPR014727 | DNA topoisomerase I, catalytic core, alpha/beta subdomain |
| Homologous_superfamily | IPR036202 | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA breaking-rejoining enzyme, catalytic core | DNA topoisomerase I | DNA topoisomerase I, active site | DNA topoisomerase IB | DNA topoisomerase I, catalytic core, alpha/beta subdomain | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type | DNA topoisomerase I, catalytic core, eukaryotic-type | DNA topoisomerase I, DNA-binding domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, eukaryotic-type | Topoisomerase I C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6T721
|
600 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available