ZFIN is now using GRCz12tu for Genomic Data
Gene
esrrgb
- ID
- ZDB-GENE-040616-4
- Name
- estrogen related receptor gamma b
- Symbol
- esrrgb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including nuclear steroid receptor activity; steroid binding activity; and zinc ion binding activity. Acts upstream of or within otic vesicle development and otolith formation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in congenital nonprogressive movement disorder with ataxia and eye movement abnormalities. Orthologous to human ESRRG (estrogen related receptor gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- ay556399 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tohmé et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonprogressive movement disorder with ataxia and eye movement abnormalities | Alliance | Movement disorder, congenital nonprogressive, with ataxia and eye movement abnormalities | 621639 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR027289 | Oestrogen-related receptor |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Oestrogen-related receptor | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RJ38 | InterPro | 444 | ||||||||
| UniProtKB:B3DIZ0 | InterPro | 420 | ||||||||
| UniProtKB:A0AC58I2I3 | InterPro | 444 | ||||||||
| UniProtKB:A0AC58I2I4 | InterPro | 444 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
esrrgb-201
(1)
|
Ensembl | 1,825 nt | ||
| mRNA |
esrrgb-202
(1)
|
Ensembl | 1,372 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers