Gene
dzip1
- ID
- ZDB-GENE-040526-1
- Name
- DAZ interacting zinc finger protein 1
- Symbol
- dzip1 Nomenclature History
- Previous Names
-
- igu
- iguana
- si:dz52i16.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable BBSome binding activity and molecular adaptor activity. Acts upstream of or within several processes, including circulatory system development; plasma membrane bounded cell projection organization; and regulation of signal transduction. Located in several cellular components, including ciliary basal body; non-motile cilium; and nucleus. Used to study coloboma. Human ortholog(s) of this gene implicated in mitral valve prolapse and spermatogenic failure 47. Orthologous to human DZIP1 (DAZ interacting zinc finger protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu116 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 31 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fo10a | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| i33 | Allele with one point mutation | Unknown | Unknown | ENU | |
| la025733Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025734Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025735Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8922 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20624 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26672 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tm79a | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ts294e | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dzip1 | N/A | (3) |
| MO2-dzip1 | N/A | (2) |
| MO3-dzip1 | N/A | Wolff et al., 2004 |
| MO4-dzip1 | N/A | Wolff et al., 2004 |
| MO5-dzip1 | N/A | Wolff et al., 2004 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitral valve prolapse | Alliance | ?Mitral valve prolapse 3 | 610840 |
| spermatogenic failure 47 | Alliance | Spermatogenic failure 47 | 619102 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | dzip1ts294e/ts294e | standard conditions | Nandamuri et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cilium assembly protein DZIP1, N-terminal | DZIP and RILPL | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:F1QNW2 | InterPro | 897 | |||
| UniProtKB:F1QHQ9 | InterPro | 877 | |||
| UniProtKB:A0A8M2BCZ0 | InterPro | 887 | |||
| UniProtKB:Q7T019 | InterPro | 898 | |||
| UniProtKB:A0A8M2BD71 | InterPro | 907 | |||
| UniProtKB:A0A8M3AT21 | InterPro | 860 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:GFP-dzip1) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-181L5 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-52I16 | ||
| Contained in | PAC | BUSM1-228E24 | ||
| Encodes | EST | eu116 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193730 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193744 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001312898 (1) | 3325 nt | ||
| Genomic | GenBank:BX649550 (1) | 170472 nt | ||
| Polypeptide | UniProtKB:A0A8M2BD71 (1) | 907 aa |
- Lv, Y., Li, J., Yu, S., Zhang, Y., Hu, H., Sun, K., Jia, D., Han, Y., Tu, J., Huang, Y., Liu, X., Zhang, X., Gao, P., Chen, X., Shaw Williams, M.T., Tang, Z., Shu, X., Liu, M., Ren, X. (2024) The splicing factor Prpf31 is required for hematopoietic stem and progenitor cell expansion during zebrafish embryogenesis. The Journal of biological chemistry. 300(3):105772
- Turgeon, A., Fu, J., Divyanshi, ., Ma, M., Jin, Z., Hwang, H., Li, M., Qiao, H., Mei, W., Yang, J. (2024) Dzip1 is dynamically expressed in the vertebrate germline and regulates the development of Xenopus primordial germ cells. Developmental Biology. 514:28-36
- Nandamuri, S.P., Lusk, S., Kwan, K.M. (2022) Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma. PLoS One. 17:e0265327
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Campinho, P., Lamperti, P., Boselli, F., Vilfan, A., Vermot, J. (2020) Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta. Cell Reports. 31:107505
- Peralta, M., Ortiz Lopez, L., Jerabkova, K., Lucchesi, T., Vitre, B., Han, D., Guillemot, L., Dingare, C., Sumara, I., Mercader, N., Lecaudey, V., Delaval, B., Meilhac, S.M., Vermot, J. (2020) Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis. Cell Reports. 32:107932
- Jacobs, C.T., Huang, P. (2019) Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish. eLIFE. 8:
- Cantaut-Belarif, Y., Sternberg, J.R., Thouvenin, O., Wyart, C., Bardet, P.L. (2018) The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Current biology : CB. 28(15):2479-2486.e4
- Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775
- Hudish, L.I., Galati, D.F., Ravanelli, A.M., Pearson, C.G., Huang, P., Appel, B. (2016) miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development (Cambridge, England). 143(13):2292-304
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