Gene

eif4a3

ID

ZDB-GENE-040426-915

Name

eukaryotic translation initiation factor 4A3

Symbol

eif4a3 Nomenclature History

Previous Names

ddx48
zgc:56139 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have RNA helicase activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to U2-type catalytic step 1 spliceosome; catalytic step 2 spliceosome; and nucleolus. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56139 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Wang et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif4a3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Robin sequence with cleft mandible and limb anomalies	268305

Associated With eif4a3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase