Gene
wwox
- ID
- ZDB-GENE-040426-858
- Name
- WW domain containing oxidoreductase
- Symbol
- wwox Nomenclature History
- Previous Names
-
- zgc:55975 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Acts upstream of or within cellular calcium ion homeostasis. Predicted to be located in cytoplasm and nucleus. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55975 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Tsuruwaka et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 12 | Alliance | Spinocerebellar ataxia, autosomal recessive 12 | 614322 |
| developmental and epileptic encephalopathy 28 | Alliance | Developmental and epileptic encephalopathy 28 | 616211 |
| esophageal cancer | Alliance | Esophageal squamous cell carcinoma, somatic | 133239 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase SDR | WW domain | WW domain superfamily | WWOX, classical (c)-like SDR domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q803A8
|
412 |
Interactions and Pathways
No data available
Plasmids
No data available