Gene
tyms
- ID
- ZDB-GENE-040426-59
- Name
- thymidylate synthetase
- Symbol
- tyms Nomenclature History
- Previous Names
-
- zgc:56465
- zgc:77659
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits thymidylate synthase activity. Involved in dTMP biosynthetic process and retina development in camera-type eye. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Is expressed in several structures, including anterior neural tube; blood; nervous system; optic vesicle; and ventral mesoderm. Orthologous to human TYMS (thymidylate synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56465 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| digenic dyskeratosis congenita | Alliance | Dyskeratosis congenita, digenic | 620040 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020940 | Thymidylate synthase, active site |
| Domain | IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain |
| Family | IPR000398 | Thymidylate synthase |
| Family | IPR045097 | Thymidylate synthase/dCMP hydroxymethylase |
| Homologous_superfamily | IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily |
Domain Details Per Protein
| Protein | Length | Thymidylate synthase | Thymidylate synthase, active site | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase domain | Thymidylate synthase/dCMP hydroxymethylase superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6P045
|
318 |
Interactions and Pathways
No data available
Plasmids
No data available