Gene

timp2b

ID
ZDB-GENE-040426-2655
Name
TIMP metallopeptidase inhibitor 2b
Symbol
timp2b Nomenclature History
Previous Names
  • timp2l
  • zgc:65967
  • zgc:85799
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to localize to extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in Moyamoya disease. Is expressed in caudal vein plexus and vasculature. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Charlton-Perkins et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With timp2b Human Ortholog
No data available
Associated With timp2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001134 Netrin domain
Family IPR001820 Protease inhibitor I35 (TIMP)
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal
Domain Details Per Protein
Protein Length Netrin domain Protease inhibitor I35 (TIMP) Proteinase inhibitor I35b (TIMP), C-terminal Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:Q6NUX9 217
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations