Gene
mre11a
- ID
- ZDB-GENE-040426-2638
- Name
- MRE11 homolog A, double strand break repair nuclease
- Symbol
- mre11a Nomenclature History
- Previous Names
-
- fc38f05
- wu:faa63d12
- wu:fc38f05
- zgc:64018
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have 3'-5'-exodeoxyribonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in mitotic DNA damage checkpoint and nucleic acid metabolic process. Predicted to colocalize with nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Is expressed in alar plate midbrain region; digestive system; eye; immature eye; and midbrain. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64018 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ataxia-telangiectasia-like disorder-1 | Alliance | Ataxia-telangiectasia-like disorder 1 | 604391 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| Domain | IPR007281 | Mre11, DNA-binding |
| Domain | IPR041796 | Mre11 nuclease, N-terminal metallophosphatase domain |
| Family | IPR003701 | DNA double-strand break repair protein Mre11 |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR038487 | Mre11, capping domain |
Domain Details Per Protein
| Protein | Length | Calcineurin-like phosphoesterase domain, ApaH type | DNA double-strand break repair protein Mre11 | Metallo-dependent phosphatase-like | Mre11, capping domain | Mre11, DNA-binding | Mre11 nuclease, N-terminal metallophosphatase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QPT3
|
700 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available