Gene

ercc1

ID
ZDB-GENE-040426-2606
Name
excision repair cross-complementation group 1
Symbol
ercc1 Nomenclature History
Previous Names
  • zgc:77511
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to localize to ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including bone cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); kidney failure; and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zaksauskaite et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ercc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebrooculofacioskeletal syndrome 4 Alliance Cerebrooculofacioskeletal syndrome 4 610758
Associated With ercc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR047260 ERCC1-like, central domain
Family IPR004579 ERCC1/RAD10/SWI10 family
Homologous_superfamily IPR010994 RuvA domain 2-like
Homologous_superfamily IPR011335 Restriction endonuclease type II-like
Domain Details Per Protein
Protein Length ERCC1-like, central domain ERCC1/RAD10/SWI10 family Restriction endonuclease type II-like RuvA domain 2-like
UniProtKB:Q6NY87 342
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations