Gene
orc4
- ID
- ZDB-GENE-040426-2224
- Name
- origin recognition complex, subunit 4
- Symbol
- orc4 Nomenclature History
- Previous Names
-
- fc50c03
- wu:fc50c03
- zgc:85772
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have DNA replication origin binding activity. Predicted to be involved in DNA replication initiation. Predicted to localize to nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Idilli et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Maerz et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 2 | Alliance | Meier-Gorlin syndrome 2 | 613800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR032705 | Origin recognition complex subunit 4, C-terminal |
| Domain | IPR041664 | Orc1-like, AAA ATPase domain |
| Family | IPR016527 | Origin recognition complex subunit 4 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | Orc1-like, AAA ATPase domain | Origin recognition complex subunit 4 | Origin recognition complex subunit 4, C-terminal | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6NWF3
|
432 | |||||
|
UniProtKB:A0A8M9QFA6
|
284 | |||||
|
UniProtKB:F1QRE0
|
432 |
Interactions and Pathways
No data available
Plasmids
No data available