Gene
polr1b
- ID
- ZDB-GENE-040426-1598
- Name
- RNA polymerase I subunit B
- Symbol
- polr1b Nomenclature History
- Previous Names
-
- wu:fc91a05
- zgc:66298 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription, DNA-templated. Predicted to localize to RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; eye; liver; musculature system; and optic tectum. Orthologous to human POLR1B (RNA polymerase I subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113960 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Sanchez et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Treacher Collins syndrome 4 | Alliance | Treacher-Collins syndrome 4 | 618939 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Treacher Collins syndrome | AB + MO1-polr1b | standard conditions | Sanchez et al., 2019 |
| Treacher Collins syndrome | hu5910Tg + MO1-polr1b | standard conditions | Sanchez et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR007121 | RNA polymerase, beta subunit, conserved site |
| Domain | IPR007120 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain |
| Domain | IPR007641 | RNA polymerase Rpb2, domain 7 |
| Domain | IPR007642 | RNA polymerase Rpb2, domain 2 |
| Domain | IPR007644 | RNA polymerase, beta subunit, protrusion |
| Domain | IPR007645 | RNA polymerase Rpb2, domain 3 |
| Domain | IPR009674 | DNA-directed RNA polymerase I subunit RPA2, domain 4 |
| Family | IPR015712 | DNA-directed RNA polymerase, subunit 2 |
| Homologous_superfamily | IPR014724 | RNA polymerase Rpb2, OB-fold |
| Homologous_superfamily | IPR037033 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily |
| Homologous_superfamily | IPR037034 | RNA polymerase Rpb2, domain 2 superfamily |
Domain Details Per Protein
| Protein | Length | DNA-directed RNA polymerase I subunit RPA2, domain 4 | DNA-directed RNA polymerase, subunit 2 | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily | RNA polymerase, beta subunit, conserved site | RNA polymerase, beta subunit, protrusion | RNA polymerase Rpb2, domain 2 | RNA polymerase Rpb2, domain 2 superfamily | RNA polymerase Rpb2, domain 3 | RNA polymerase Rpb2, domain 7 | RNA polymerase Rpb2, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4V967
|
1132 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
polr1b-201
(1)
|
Havana | 3529 nt |
Interactions and Pathways
No data available
Plasmids
No data available