Gene
pdhx
- ID
- ZDB-GENE-040426-1539
- Name
- pyruvate dehydrogenase complex component X
- Symbol
- pdhx Nomenclature History
- Previous Names
-
- zgc:66110
- zgc:85977 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be part of pyruvate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and sarcoma. Orthologous to human PDHX (pyruvate dehydrogenase complex component X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85977 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate decarboxylase deficiency | Alliance | Lacticacidemia due to PDX1 deficiency | 245349 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| Domain | IPR004167 | Peripheral subunit-binding domain |
| Family | IPR045257 | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR036625 | E3-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 2-oxo acid dehydrogenase, lipoyl-binding site | Biotin/lipoyl attachment | Chloramphenicol acetyltransferase-like domain superfamily | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component | E3-binding domain superfamily | Peripheral subunit-binding domain | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI02
|
490 | ||||||||
|
UniProtKB:F1R0J8
|
496 |
Interactions and Pathways
No data available
Plasmids
No data available