Gene
lias
- ID
- ZDB-GENE-040426-1528
- Name
- lipoic acid synthetase
- Symbol
- lias Nomenclature History
- Previous Names
-
- zgc:66080
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hyperglycinemia, lactic acidosis, and seizures | 614462 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Elp3/MiaA/NifB-like, radical SAM core domain | Lipoyl synthase | Lipoyl synthase, N-terminal | Radical SAM |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6PHG4
|
399 | |||||
|
UniProtKB:A0A0R4I9B1
|
397 |
Interactions and Pathways
No data available
Plasmids
No data available