Gene

lias

ID
ZDB-GENE-040426-1528
Name
lipoic acid synthetase
Symbol
lias Nomenclature History
Previous Names
  • zgc:66080
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lias Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hyperglycinemia, lactic acidosis, and seizures 614462
Associated With lias Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
Domain IPR007197 Radical SAM
Domain IPR031691 Lipoyl synthase, N-terminal
Family IPR003698 Lipoyl synthase
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel Elp3/MiaA/NifB-like, radical SAM core domain Lipoyl synthase Lipoyl synthase, N-terminal Radical SAM
UniProtKB:Q6PHG4 399
UniProtKB:A0A0R4I9B1 397
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations