Gene
clcnk
- ID
- ZDB-GENE-040426-1379
- Name
- chloride channel K
- Symbol
- clcnk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables chloride transmembrane transporter activity. Involved in chloride ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in renal system. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64141 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Pérez-Rius et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bartter disease type 3 | Alliance | Bartter syndrome, type 3 | 607364 |
| Bartter disease type 4b | Alliance | Bartter syndrome, type 4b, digenic | 613090 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CBS domain | CBS domain superfamily | Chloride channel, core | Chloride channel, voltage gated | Voltage-gated chloride channel |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PKM9
|
724 | |||||
|
UniProtKB:Q7T329
|
693 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available