Gene

sord

ID

ZDB-GENE-040426-1231

Name

sorbitol dehydrogenase

Symbol

sord Nomenclature History

Previous Names

zgc:63674

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in sorbitol catabolic process. Predicted to be located in motile cilium. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sord Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive distal hereditary motor neuronopathy 8	Alliance	Neuronopathy, distal hereditary motor, autosomal recessive 8	618912

Associated With sord Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
Domain	IPR013149	Alcohol dehydrogenase-like, C-terminal
Domain	IPR013154	Alcohol dehydrogenase-like, N-terminal
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Family	IPR045306	Sorbitol dehydrogenase-like
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily