Gene

rxfp2a

ID

ZDB-GENE-040426-1225

Name

relaxin family peptide receptor 2a

Symbol

rxfp2a Nomenclature History

Previous Names

rxfp2
rxfp2b
zgc:63668

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have G protein-coupled peptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and hormone-mediated signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in cryptorchidism. Is expressed in female organism; male organism; and ovary. Orthologous to human RXFP2 (relaxin family peptide receptor 2).

Genome Resources

Note

In March of 2012 this gene was found to be orthologous (both AA and synteny) to human and mouse RXFP2. The curator named this gene rxfp2b, in accordance with Zebrafish Nomenclature Guidelines. In the same month, Yegorov and Good (2012) named this gene rxpfa. Subsequently, two additional publications have maintained Yegorov and Good's nomenclature. In November of 2015 the names and gene symbols of both paralogs were changed to reflect a request filed with NCBI that was forwarded to the ZFIN nomenclature coordinator.

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63668 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rxfp2a Human Ortholog

No data available

Associated With rxfp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR008112	Relaxin receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype