Gene

tirap

ID

ZDB-GENE-040219-4

Name

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Symbol

tirap Nomenclature History

Previous Names

mal (1)
MyD88 adapter-like protein (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in malaria; primary immunodeficiency disease; and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tirap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Bacteremia, protection against}	614382
		{Malaria, protection against}	611162
		{Tuberculosis, protection against}	607948

Associated With tirap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Family	IPR017279	Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily

Domain Details Per Protein

Protein	Length	Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap	Toll/interleukin-1 receptor homology (TIR) domain	Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:A0A8M6Z2S6 InterPro	243
UniProtKB:A0A8M1REJ6 InterPro	226

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tirap-201 (1) Ensembl	Ensembl		612 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations