Gene
gpc3
- ID
- ZDB-GENE-031212-1
- Name
- glypican 3
- Symbol
- gpc3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Involved in cell migration involved in gastrulation and negative regulation of canonical Wnt signaling pathway. Predicted to localize to anchored component of plasma membrane; cell surface; and extracellular region. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Is expressed in intestine; liver; and midbrain. Orthologous to human GPC3 (glypican 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephroblastoma | Alliance | Wilms tumor, somatic | 194070 |
| Simpson-Golabi-Behmel syndrome type 1 | Alliance | Simpson-Golabi-Behmel syndrome, type 1 | 312870 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001863 | Glypican |
Domain Details Per Protein
| Protein | Length | Glypican |
|---|---|---|
|
UniProtKB:Q6V9Y8
|
590 |
Interactions and Pathways
Plasmids
No data available