Gene

aph1b

ID
ZDB-GENE-031118-31
Name
APH1B gamma secretase subunit
Symbol
aph1b Nomenclature History
Previous Names
  • wu:fc41h05 (1)
  • wu:fi53a04 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have endopeptidase activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to localize to endoplasmic reticulum; gamma-secretase complex; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Orthologous to several human genes including APH1B (aph-1 homolog B, gamma-secretase subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Campbell et al., 2006
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Campbell et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aph1b Human Ortholog
No data available
Associated With aph1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR009294 Gamma-secretase subunit Aph-1
Domain Details Per Protein
Protein Length Gamma-secretase subunit Aph-1
UniProtKB:Q8JHE9 258
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations