Gene

satb1a

ID

ZDB-GENE-031010-36

Name

SATB homeobox 1a

Symbol

satb1a Nomenclature History

Previous Names

sb:cb955
si:ch211-195k18.2 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in basal plate midbrain region and nervous system. Orthologous to human SATB1 (SATB homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb955 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With satb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		den Hoed-de Boer-Voisin syndrome	619229
		Developmental delay with dysmorphic facies and dental anomalies	619228

Associated With satb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003350	CUT domain
Domain	IPR032355	SATB, CUT1-like DNA-binding domain
Domain	IPR032392	SATB, ubiquitin-like oligomerisation domain
Family	IPR039673	DNA-binding protein SATB1/SATB2
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
Homologous_superfamily	IPR038216	SATB, CUTL domain superfamily
Homologous_superfamily	IPR038224	SATB, ULD domain superfamily