Gene
atrx
- ID
- ZDB-GENE-030912-11
- Name
- ATRX chromatin remodeler
- Symbol
- atrx Nomenclature History
- Previous Names
-
- wu:fb26e12
- wu:fb52h08
- wu:fb72g09
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and metal ion binding activity. Human ortholog(s) of this gene implicated in alpha thalassemia-X-linked intellectual disability syndrome and malignant glioma. Orthologous to human ATRX (ATRX chromatin remodeler).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66223 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Oppel et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha thalassemia-X-linked intellectual disability syndrome | Alliance | Alpha-thalassemia/impaired intellectual development syndrome | 301040 |
| alpha-thalassemia myelodysplasia syndrome | Alliance | Alpha-thalassemia myelodysplasia syndrome, somatic | 300448 |
| Intellectual disability-hypotonic facies syndrome, X-linked | 309580 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| alpha thalassemia-X-linked intellectual disability syndrome | atrxzdf36/zdf36 (AB) | standard conditions | Oppel et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR025766 | ADD domain |
| Domain | IPR041430 | ATRX, ADD domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | ADD domain | ATRX, ADD domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | Zinc finger, FYVE/PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QKH6
|
2053 | |||||||||
|
UniProtKB:E7F4M2
|
2013 |
Interactions and Pathways
No data available
Plasmids
No data available