Gene
drd2l
- ID
- ZDB-GENE-030910-1
- Name
- dopamine receptor D2 like
- Symbol
- drd2l Nomenclature History
- Previous Names
-
- drd2b (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have adrenergic receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; behavioral response to cocaine; and regulation of ion transport. Predicted to localize to integral component of plasma membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); end stage renal failure; mental depression; obesity; and type 2 diabetes mellitus. Is expressed in brain and spinal cord. Orthologous to human DRD2 (dopamine receptor D2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Liu et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa36274 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Dopamine D2 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
---|---|---|---|---|---|
UniProtKB:Q7T1A2
|
437 | ||||
UniProtKB:X1WBR1
|
450 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-348D11 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-439N16 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_197935 (1) | 1327 nt | ||
Genomic | GenBank:CU694229 (2) | 41447 nt | ||
Polypeptide | UniProtKB:X1WBR1 (1) | 450 aa |
No data available
- Zhou, J., Peng, C., Li, Q., Yan, X., Yang, L., Li, M., Cao, X., Xie, X., Chen, D., Rao, C., Huang, S., Peng, F., Pan, X. (2022) Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells. Frontiers in pharmacology. 13:837810
- Li, X., Liu, H., Li, D., Lei, H., Wei, X., Schlenk, D., Mu, J., Chen, H., Yan, B., Xie, L. (2021) Dietary Seleno-l-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio). Environmental science & technology. 55:11894-11905
- Li, Z., Cao, P., Meng, H., Li, D., Zhang, Y., Li, Y., Wang, S. (2021) Long-term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline can trigger a potential risk of Parkinson's disease. Journal of hazardous materials. 412:125230
- Roche, J., Hergalant, S., Depp, A., Ben Ammar, I., Lafont, A.G., Policar, T., Fontaine, P., Milla, S. (2020) First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 36:100747
- Li, R., Guo, W., Lei, L., Zhang, L., Liu, Y., Han, J., Chen, L., Zhou, B. (2019) Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish. Environment International. 134:105293
- Lv, D.J., Li, L.X., Chen, J., Wei, S.Z., Wang, F., Hu, H., Xie, A.M., Liu, C.F. (2019) Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson's Disease. Behavioural brain research. 372:112031
- Naderi, M., Salahinejad, A., Ferrari, M.C.O., Niyogi, S., Chivers, D.P. (2018) Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium. Environmental pollution (Barking, Essex : 1987). 237:174-185
- Opazo, J.C., Zavala, K., Miranda-Rottmann, S., Araya, R. (2018) Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages. PeerJ. 6:e4593
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Naderi, M., Salahinejad, A., Jamwal, A., Chivers, D.P., Niyogi, S. (2017) Chronic dietary selenomethionine exposure induces oxidative stress, dopaminergic dysfunction, and cognitive impairment in adult zebrafish (Danio rerio). Environmental science & technology. 51(21):12879-12888
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