Gene

p4ha2

ID

ZDB-GENE-030827-1

Name

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2

Symbol

p4ha2 Nomenclature History

Previous Names

prolyl 4-hydroxylase A (1)
zgc:91948

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to contribute to procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in myopia. Is expressed in several structures, including axis; heart rudiment; margin; notochord; and tail bud. Orthologous to human P4HA2 (prolyl 4-hydroxylase subunit alpha 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91948 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With p4ha2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Myopia 25, autosomal dominant	617238

Associated With p4ha2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR013547	Prolyl 4-hydroxylase alpha-subunit, N-terminal
Domain	IPR044862	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Family	IPR045054	Prolyl 4-hydroxylase
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Oxoglutarate/iron-dependent dioxygenase domain	Prolyl 4-hydroxylase	Prolyl 4-hydroxylase, alpha subunit	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	Prolyl 4-hydroxylase alpha-subunit, N-terminal	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:A0A286Y8C8 InterPro	536
UniProtKB:A0A8M2BL82 InterPro	542
UniProtKB:Q6DG45 InterPro	514
UniProtKB:A0A8M3ALV0 InterPro	520
UniProtKB:A0A8M2BL71 InterPro	534
UniProtKB:A0A8M3AX68 InterPro	540

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	p4ha2-201 (1) Ensembl	Ensembl	1,938 nt	Select Tool ZFIN BLAST
mRNA	p4ha2-202 (1) Ensembl	Ensembl	1,477 nt	Select Tool ZFIN BLAST
mRNA	p4ha2-203 (1) Ensembl	Ensembl	1,583 nt	Select Tool ZFIN BLAST
mRNA	p4ha2-204 (1) Ensembl	Ensembl	1,938 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations