Gene

lamp2

ID

ZDB-GENE-030729-9

Name

lysosomal-associated membrane protein 2

Symbol

lamp2 Nomenclature History

Previous Names

sb:cb587
wu:fb14a06
zgc:103532

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Acts upstream of or within macroautophagy. Predicted to be located in lysosome and membrane. Predicted to be active in bounding membrane of organelle and plasma membrane. Is expressed in cardiovascular system; heart; solid lens vesicle; vein; and yolk syncytial layer. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb587 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Dvornikov et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lamp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Danon disease	Alliance	Danon disease	300257

Associated With lamp2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Danon disease	lamp2^xu082/xu082 (WIK)	standard conditions	Dvornikov et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR048524	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
Domain	IPR048528	Lysosome-associated membrane glycoprotein 2-like, luminal domains
Family	IPR002000	Lysosome-associated membrane glycoprotein

Domain Details Per Protein

Protein	Length	Lysosome-associated membrane glycoprotein	Lysosome-associated membrane glycoprotein 2-like, luminal domains	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain
UniProtKB:Q5BKX3 InterPro	355
UniProtKB:A0A2R8Q0I4 InterPro	358
UniProtKB:A0A0R4IZ00 InterPro	356

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lamp2-201 (1) Ensembl	Ensembl	2,432 nt	Select Tool ZFIN BLAST
mRNA	lamp2-202 (1) Ensembl	Ensembl	786 nt	Select Tool ZFIN BLAST
mRNA	lamp2-204 (1) Ensembl	Ensembl	826 nt	Select Tool ZFIN BLAST
mRNA	lamp2-206 (1) Ensembl	Ensembl	893 nt	Select Tool ZFIN BLAST
mRNA	lamp2-207 (1) Ensembl	Ensembl	1,245 nt	Select Tool ZFIN BLAST
mRNA	lamp2-208 (1) Ensembl	Ensembl	1,242 nt	Select Tool ZFIN BLAST
mRNA	lamp2-209 (1) Ensembl	Ensembl	1,251 nt	Select Tool ZFIN BLAST
mRNA	lamp2-210 (1) Ensembl	Ensembl	1,263 nt	Select Tool ZFIN BLAST
ncRNA	lamp2-003 (1) Ensembl	Ensembl	432 nt	Select Tool ZFIN BLAST
ncRNA	lamp2-006 (1) Ensembl	Ensembl	593 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations