Gene
tap2a
- ID
- ZDB-GENE-030616-245
- Name
- transporter associated with antigen processing, subunit type a
- Symbol
- tap2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type peptide transporter activity. Acts upstream of or within response to cadmium ion. Predicted to be located in endoplasmic reticulum membrane and mitochondrial inner membrane. Predicted to be part of MHC class I peptide loading complex. Predicted to be active in membrane. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in several diseases, including aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Gonzalez et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q801W2 | InterPro | 725 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | abcb3l1-001 (1) | Havana | 2,178 nt | ||
| mRNA |
tap2a-201
(1)
|
Ensembl | 3,190 nt |
Interactions and Pathways
No data available
Plasmids
No data available