Gene

cars1

ID

ZDB-GENE-030328-29

Name

cysteinyl-tRNA synthetase 1

Symbol

cars1 Nomenclature History

Previous Names

cars
sb:cb71 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to localize to cytoplasm. Is expressed in several structures, including eye; hatching gland; pectoral fin musculature; polster; and tail bud. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb71 (16 images)
IMAGE:7152122 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Busch-Nentwich et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cars1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Microcephaly, developmental delay, and brittle hair syndrome	618891

Associated With cars1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032678	tRNA synthetases class I, catalytic domain
Family	IPR015803	Cysteine-tRNA ligase
Family	IPR024909	Cysteinyl-tRNA synthetase/mycothiol ligase
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036282	Glutathione S-transferase, C-terminal domain superfamily