Gene
skp2
- ID
- ZDB-GENE-030219-158
- Name
- S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- Symbol
- skp2 Nomenclature History
- Previous Names
-
- id:ibd5121
- sb:cb933
- wu:fa10b08
- wu:fj97b11
- zgc:162950
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and regulation of cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb933 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | F-box domain | F-box-like domain superfamily | Leucine-rich repeat, cysteine-containing subtype | Leucine-rich repeat domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A3KP53
|
410 | ||||
|
UniProtKB:A0A8M2B860
|
427 |
Interactions and Pathways
No data available
Plasmids
No data available