Gene
bmper
- ID
- ZDB-GENE-030219-146
- Name
- BMP binding endothelial regulator
- Symbol
- bmper Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables extracellular matrix binding activity. Acts upstream of or within several processes, including neural crest formation; otic placode formation; and regulation of BMP signaling pathway. Located in extracellular matrix and extracellular space. Is expressed in several structures, including head; hematopoietic system; mesoderm; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diaphanospondylodysostosis | 608022 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001846 | von Willebrand factor, type D domain |
| Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
| Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
| Family | IPR052424 | Kielin/Chordin-like & BMP-binding Regulator |
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Domain Details Per Protein
| Protein | Length | Kielin/Chordin-like & BMP-binding Regulator | Serine protease inhibitor-like superfamily | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWFC domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A6H8K2
|
668 | ||||||
|
UniProtKB:Q5D734
|
668 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-402O14 | ZFIN Curated Data | |
| Encodes | EST | ibd5071 | ||
| Encodes | cDNA | MGC:162070 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193655 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020487 (1) | 3217 nt | ||
| Genomic | GenBank:CU683894 (2) | 36404 nt | ||
| Polypeptide | UniProtKB:A6H8K2 (1) | 668 aa |
- Zhang, D., Zhou, F., Zhao, X., Liu, B., Chen, J., Yang, J. (2019) Endoglin is a conserved regulator of vasculogenesis in zebrafish-Implications for hereditary haemorrhagic telangiectasia. Bioscience Reports. 39(5):
- Esser, J.S., Steiner, R.E., Deckler, M., Schmitt, H., Engert, B., Link, S., Charlet, A., Patterson, C., Bode, C., Zhou, Q., Moser, M. (2018) Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. The FEBS journal. 285(8):1419-1436
- Li, L., Mao, A., Wang, P., Ning, G., Cao, Y., Wang, Q. (2018) Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation.. Biology Open. 7(12):
- Ben-Moshe Livne, Z., Alon, S., Vallone, D., Bayleyen, Y., Tovin, A., Shainer, I., Nisembaum, L.G., Aviram, I., Smadja-Storz, S., Fuentes, M., Falcón, J., Eisenberg, E., Klein, D.C., Burgess, H.A., Foulkes, N.S., Gothilf, Y. (2016) Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. PLoS Genetics. 12:e1006445
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One. 9:e90568
- Yao, D., Zhao, F., Wu, Y., Wang, J., Wei, D., Zhao, J., Zhu, Z., Liu, D. (2014) Dissecting the differentiation process of the pre-placodal ectoderm in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(10):1338-51
- Heinke, J., Juschkat, M., Charlet, A., Mnich, L., Helbing, T., Bode, C., Patterson, C., and Moser, M. (2013) Antagonism and synergy between extracellular BMP modulators Tsg and BMPER to balance blood vessel formation. Journal of Cell Science. 126(Pt 14):3082-94
- Jia, Q., Zhang, Q., Zhang, Z., Wang, Y., Zhang, W., Zhou, Y., Wan, Y., Cheng, T., Zhu, X., Fang, X., Yuan, W., and Jia, H. (2013) Transcriptome Analysis of the Zebrafish Model of Diamond-Blackfan Anemia from RPS19 Deficiency via p53-Dependent and -Independent Pathways. PLoS One. 8(8):e71782
- Reichert, S., Randall, R.A., and Hill C.S. (2013) A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development (Cambridge, England). 140(21):4435-4444
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