Gene
g6pd
- ID
- ZDB-GENE-070508-4
- Name
- glucose-6-phosphate dehydrogenase
- Symbol
- g6pd Nomenclature History
- Previous Names
-
- fj78b06
- si:dkey-90a13.8
- wu:fj78b06
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Exhibits glucose-6-phosphate dehydrogenase activity. Involved in epiboly. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia | Alliance | Hemolytic anemia, G6PD deficient (favism) | 300908 |
| {Resistance to malaria due to G6PD deficiency} | 611162 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hemolytic anemia | AB + CRISPR1-g6pd | standard conditions | Hwang et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR019796 | Glucose-6-phosphate dehydrogenase, active site |
| Domain | IPR022674 | Glucose-6-phosphate dehydrogenase, NAD-binding |
| Domain | IPR022675 | Glucose-6-phosphate dehydrogenase, C-terminal |
| Family | IPR001282 | Glucose-6-phosphate dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Glucose-6-phosphate dehydrogenase | Glucose-6-phosphate dehydrogenase, active site | Glucose-6-phosphate dehydrogenase, C-terminal | Glucose-6-phosphate dehydrogenase, NAD-binding | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PWR3
|
513 | |||||
|
UniProtKB:A0A8M9PDT5
|
523 | |||||
|
UniProtKB:A0A8M2B959
|
534 | |||||
|
UniProtKB:E7FDY7
|
513 | |||||
|
UniProtKB:A0A8M3AY75
|
528 | |||||
|
UniProtKB:A0A8M9Q7P5
|
534 | |||||
|
UniProtKB:F6NHI0
|
523 | |||||
|
UniProtKB:A0A8M9Q3J7
|
528 |
Interactions and Pathways
No data available
Plasmids
No data available