Gene
lig3
- ID
- ZDB-GENE-030131-8453
- Name
- ligase III, DNA, ATP-dependent
- Symbol
- lig3 Nomenclature History
- Previous Names
-
- im:7139055
- im:7145225
- wu:fb12c02
- wu:fd10b03
- wu:fm79b09
- zgc:112973
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA ligase (ATP) activity. Acts upstream of or within double-strand break repair via alternative nonhomologous end joining. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 20 and pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 20 | Alliance | Mitochondrial DNA depletion syndrome 20 (MNGIE type) | 619780 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016059 | DNA ligase, ATP-dependent, conserved site |
| Domain | IPR001357 | BRCT domain |
| Domain | IPR001510 | Zinc finger, PARP-type |
| Domain | IPR012308 | DNA ligase, ATP-dependent, N-terminal |
| Domain | IPR012309 | DNA ligase, ATP-dependent, C-terminal |
| Domain | IPR012310 | DNA ligase, ATP-dependent, central |
| Domain | IPR031916 | DNA ligase 3, BRCT domain |
| Family | IPR000977 | DNA ligase, ATP-dependent |
| Family | IPR050191 | ATP-dependent DNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
| Homologous_superfamily | IPR036599 | DNA ligase, ATP-dependent, N-terminal domain superfamily |
| Homologous_superfamily | IPR036957 | Zinc finger, PARP-type superfamily |
Domain Details Per Protein
| Protein | Length | ATP-dependent DNA ligase | BRCT domain | BRCT domain superfamily | DNA ligase 3, BRCT domain | DNA ligase, ATP-dependent | DNA ligase, ATP-dependent, central | DNA ligase, ATP-dependent, conserved site | DNA ligase, ATP-dependent, C-terminal | DNA ligase, ATP-dependent, N-terminal | DNA ligase, ATP-dependent, N-terminal domain superfamily | Nucleic acid-binding, OB-fold | Zinc finger, PARP-type | Zinc finger, PARP-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJL4
|
1011 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available