Gene
cnksr2b
- ID
- ZDB-GENE-030131-8048
- Name
- connector enhancer of kinase suppressor of Ras 2b
- Symbol
- cnksr2b Nomenclature History
- Previous Names
-
- fj48e09
- si:dkey-92k1.12
- wu:fj48e09 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation and regulation of signal transduction. Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked mental retardation Hough type | Alliance | Intellectual developmental disorder, X-linked syndromic, Houge type | 301008 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR010599 | Connector enhancer of kinase suppressor of ras 2/3 domain |
| Domain | IPR017874 | CRIC domain |
| Domain | IPR049628 | CNK1-3, SAM domain |
| Family | IPR051566 | Connector enhancer of kinase suppressor of Ras |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CNK1-3, SAM domain | Connector enhancer of kinase suppressor of Ras | Connector enhancer of kinase suppressor of ras 2/3 domain | CRIC domain | PDZ domain | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FAZ0 | InterPro | 963 | ||||||||||
| UniProtKB:A0A8M3AM98 | InterPro | 969 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnksr2b-201
(1)
|
Ensembl | 3,352 nt | ||
| mRNA |
cnksr2b-203
(1)
|
Ensembl | 2,409 nt | ||
| mRNA |
cnksr2b-204
(1)
|
Ensembl | 7,988 nt | ||
| ncRNA |
cnksr2b-002
(1)
|
Ensembl | 494 nt |
Interactions and Pathways
No data available
Plasmids
No data available