Gene
mak
- ID
- ZDB-GENE-030131-7279
- Name
- male germ cell-associated kinase
- Symbol
- mak Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Involved in cilium assembly and photoreceptor cell outer segment organization. Acts upstream of or within motile cilium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cilium; cytoplasm; and nucleus. Is expressed in several structures, including Kupffer's vesicle; brain; forerunner cell group; optic cup; and visual system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56603 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 62 | Alliance | Retinitis pigmentosa 62 | 614181 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050117 | Mitogen-activated protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QUT2 | InterPro | 633 | |||||
| UniProtKB:A0A8M9PFV2 | InterPro | 590 | |||||
| UniProtKB:A0A8M3ANF8 | InterPro | 600 | |||||
| UniProtKB:A0A8M2B9R2 | InterPro | 601 | |||||
| UniProtKB:Q7ZTX0 | InterPro | 633 | |||||
| UniProtKB:A0A286Y937 | InterPro | 632 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids