Gene

pms2

ID
ZDB-GENE-030131-686
Name
PMS1 homolog 2, mismatch repair system component
Symbol
pms2 Nomenclature History
Previous Names
  • wu:fb39g07
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have ATPase activity. Predicted to be involved in mismatch repair. Predicted to localize to MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pms2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary nonpolyposis colorectal cancer type 4 Alliance Lynch syndrome 4 614337
Mismatch repair cancer syndrome 4 619101
Associated With pms2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR014762 DNA mismatch repair, conserved site
Domain IPR013507 DNA mismatch repair protein, S5 domain 2-like
Domain IPR014790 MutL, C-terminal, dimerisation
Family IPR002099 DNA mismatch repair protein MutL/Mlh/PMS
Family IPR038973 DNA mismatch repair protein MutL/Mlh/Pms-like
Homologous_superfamily IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily IPR020568 Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Homologous_superfamily IPR037198 MutL, C-terminal domain superfamily
Homologous_superfamily IPR042120 MutL, C-terminal domain, dimerisation subdomain
Homologous_superfamily IPR042121 MutL, C-terminal domain, regulatory subdomain
Domain Details Per Protein
Protein Length DNA mismatch repair, conserved site DNA mismatch repair protein MutL/Mlh/PMS DNA mismatch repair protein MutL/Mlh/Pms-like DNA mismatch repair protein, S5 domain 2-like Histidine kinase/HSP90-like ATPase superfamily MutL, C-terminal, dimerisation MutL, C-terminal domain, dimerisation subdomain MutL, C-terminal domain, regulatory subdomain MutL, C-terminal domain superfamily Ribosomal protein uS5 domain 2-type superfamily Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
UniProtKB:E7F558 851
UniProtKB:A0A8N7T7Z7 852
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations