ZFIN is now using GRCz12tu for Genomic Data
Gene
psmc5
- ID
- ZDB-GENE-030131-6547
- Name
- proteasome 26S subunit, ATPase 5
- Symbol
- psmc5 Nomenclature History
- Previous Names
-
- wu:fa14g03
- wu:fb23a11
- zgc:92464
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable general transcription initiation factor binding activity; proteasome-activating activity; and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Human ortholog(s) of this gene implicated in Yu-Kury neurodevelopmental syndrome. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92464 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Yu-Kury neurodevelopmental syndrome | Alliance | Yu-Kury neurodevelopmental syndrome | 621565 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR032501 | Proteasomal ATPase, second OB domain |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR050221 | 26S Proteasome Regulatory ATPase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | 26S Proteasome Regulatory ATPase | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase | Proteasomal ATPase, second OB domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AZC1 | InterPro | 406 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers