ZFIN is now using GRCz12tu for Genomic Data
Gene
psmd12
- ID
- ZDB-GENE-030131-617
- Name
- proteasome 26S subunit, non-ATPase 12
- Symbol
- psmd12 Nomenclature History
- Previous Names
-
- fc34f08
- wu:fb38a06
- wu:fc34f08
- wu:fc49f02
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within brain development; cranial skeletal system development; and kidney development. Predicted to be part of proteasome regulatory particle, lid subcomplex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in disease of mental health. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Küry et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Stankiewicz-Isidor syndrome | 617516 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000717 | Proteasome component (PCI) domain |
| Domain | IPR040896 | 26S proteasome regulatory subunit RPN5, C-terminal domain |
| Domain | IPR054559 | PSMD12/CSN4-like, N-terminal |
| Family | IPR040134 | 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 | 26S proteasome regulatory subunit RPN5, C-terminal domain | Proteasome component (PCI) domain | PSMD12/CSN4-like, N-terminal | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AW07 | InterPro | 456 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
psmd12-201
(1)
|
Ensembl | 2,413 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers