Gene
brdt
- ID
- ZDB-GENE-030131-5928
- Name
- bromodomain, testis-specific
- Symbol
- brdt Nomenclature History
- Previous Names
-
- fi25h02
- si:dkeyp-85h7.3
- wu:fi25h02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable histone reader activity and lysine-acetylated histone binding activity. Predicted to be involved in several processes, including male meiosis I; regulation of gene expression; and sperm DNA condensation. Predicted to act upstream of or within with a positive effect on positive regulation of gene expression. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159282 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 21 | Alliance | ?Spermatogenic failure 21 | 617644 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR027353 | NET domain |
| Domain | IPR031354 | Bromodomain protein 4, C-terminal |
| Domain | IPR043508 | Brdt, bromodomain, repeat I |
| Domain | IPR043509 | Brdt, bromodomain, repeat II |
| Family | IPR050935 | Bromodomain-containing chromatin reader |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR038336 | NET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | Bromodomain protein 4, C-terminal | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IJ54 | InterPro | 979 | |||||||||
| UniProtKB:I3IS77 | InterPro | 1093 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available