Gene

porb

ID
ZDB-GENE-030131-5767
Name
P450 (cytochrome) oxidoreductase b
Symbol
porb Nomenclature History
Previous Names
  • fb60a10
  • fi17c02
  • im:7051962
  • wu:fb60a10
  • wu:fi17c02
  • zgc:63480
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have NADPH-hemoprotein reductase activity; coenzyme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in response to hormone. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome and congenital adrenal hyperplasia. Orthologous to human POR (cytochrome p450 oxidoreductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With porb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Antley-Bixler syndrome with disordered steroidogenesis Alliance Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis 201750
cytochrome P450 oxidoreductase deficiency Alliance Disordered steroidogenesis due to cytochrome P450 oxidoreductase 613571
Associated With porb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001094 Flavodoxin-like
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain IPR008254 Flavodoxin/nitric oxide synthase
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR023208 NADPH-cytochrome P450 reductase
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily IPR029039 Flavoprotein-like superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavodoxin-like Flavodoxin/nitric oxide synthase Flavoprotein-like superfamily Flavoprotein pyridine nucleotide cytochrome reductase NADPH-cytochrome P450 reductase NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily Oxidoreductase FAD/NAD(P)-binding Riboflavin synthase-like beta-barrel Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:A0A8M2BKN4
InterPro
649
UniProtKB:F8W4Z6
InterPro
671
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA porb-202 (1)
Ensembl
Ensembl 3,439 nt
ncRNA porb-002 (1)
Ensembl
Ensembl 2,112 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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