mthfd2l

ID

ZDB-GENE-030131-5707

Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like

Symbol

mthfd2l Nomenclature History

Previous Names

wu:fi14c12
zgc:63479

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lee et al., 2012

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mthfd2l Human Ortholog

No data available

Associated With mthfd2l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020867	Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Domain	IPR020630	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain	IPR020631	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family	IPR000672	Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily
Homologous_superfamily	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BEG5	InterPro	348
UniProtKB:Q7SY55	InterPro	334
UniProtKB:A0AB32TWJ8	InterPro	306
UniProtKB:A0AB32TYC2	InterPro	238
UniProtKB:A0AC58G675	InterPro	273
UniProtKB:A0AC58G677	InterPro	372
UniProtKB:A0AC58G678	InterPro	238
UniProtKB:A0AC58G679	InterPro	369
UniProtKB:A0AC58G681	InterPro	261
UniProtKB:A0AC58G683	InterPro	261
UniProtKB:A0AC58G684	InterPro	273
UniProtKB:A0AC58G685	InterPro	262
UniProtKB:A0AC58G687	InterPro	238
UniProtKB:A0AC58G689	InterPro	273
UniProtKB:A0AC58G694	InterPro	224
UniProtKB:A0AC58G696	InterPro	371
UniProtKB:A0AC58G699	InterPro	238
UniProtKB:A0AC58G6A0	InterPro	224
UniProtKB:A0AC58G6C5	InterPro	238