Gene
f5
- ID
- ZDB-GENE-030131-5531
- Name
- coagulation factor V
- Symbol
- f5 Nomenclature History
- Previous Names
-
- si:bz20i5.3
- wu:fd21h06
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable copper ion binding activity and oxidoreductase activity. Acts upstream of or within blood coagulation and response to bacterium. Predicted to be located in extracellular region. Is expressed in liver. Used to study factor V deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2423 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Budd-Chiari syndrome | Alliance | {Budd-Chiari syndrome} | 600880 |
| cerebral infarction | Alliance | {Stroke, ischemic, susceptibility to} | 601367 |
| factor V deficiency | Alliance | Factor V deficiency | 227400 |
| thrombophilia due to activated protein C resistance | Alliance | Thrombophilia 2 due to activated protein C resistance | 188055 |
| thrombophilia due to activated protein C resistance | Alliance | {Thrombophilia, susceptibility to, due to factor V Leiden} | 188055 |
| {Pregnancy loss, recurrent, susceptibility to, 1} | 614389 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| factor V deficiency | f5sa13037/sa13037 | standard conditions | Dhinoja et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR011707 | Multicopper oxidase-like, N-terminal |
| Family | IPR024715 | Coagulation factor 5/8-like |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008972 | Cupredoxin |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Coagulation factor 5/8-like | Cupredoxin | Galactose-binding-like domain superfamily | Multicopper oxidase-like, N-terminal | Multicopper oxidases, conserved site | Neuropilin/Multicopper Oxidase/Coagulation Factor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B7ZVT7
|
2087 |
Interactions and Pathways
No data available
Plasmids
No data available