Gene
spg7
- ID
- ZDB-GENE-030131-5391
- Name
- SPG7 matrix AAA peptidase subunit, paraplegin
- Symbol
- spg7 Nomenclature History
- Previous Names
-
- fd15f08
- wu:fd15f08
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to be involved in mitochondrion organization. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 7 | Alliance | Spastic paraplegia 7, autosomal recessive | 607259 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000642 | Peptidase M41 |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR011546 | Peptidase M41, FtsH extracellular |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005936 | ATP-dependent zinc metalloprotease, FtsH |
| Family | IPR050928 | ATP-dependent Zinc Metalloprotease |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR037219 | Peptidase M41-like |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, core | ATP-dependent Zinc Metalloprotease | ATP-dependent zinc metalloprotease, FtsH | Peptidase M41 | Peptidase M41, FtsH extracellular | Peptidase M41-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PS13
|
751 | |||||||||
|
UniProtKB:E7F2S4
|
788 |
Interactions and Pathways
No data available
Plasmids
No data available