Gene
spg7
- ID
- ZDB-GENE-030131-5391
- Name
- SPG7 matrix AAA peptidase subunit, paraplegin
- Symbol
- spg7 Nomenclature History
- Previous Names
-
- fd15f08
- wu:fd15f08
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 7 | Alliance | Spastic paraplegia 7, autosomal recessive | 607259 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000642 | Peptidase M41 |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR011546 | Peptidase M41, FtsH extracellular |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005936 | ATP-dependent zinc metalloprotease, FtsH |
| Family | IPR050928 | ATP-dependent Zinc Metalloprotease |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR037219 | Peptidase M41-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, core | ATP-dependent Zinc Metalloprotease | ATP-dependent zinc metalloprotease, FtsH | Peptidase M41 | Peptidase M41, FtsH extracellular | Peptidase M41-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PS13 | InterPro | 751 | |||||||||
| UniProtKB:E7F2S4 | InterPro | 788 |
Interactions and Pathways
No data available
Plasmids
No data available