Gene

mrm2

ID

ZDB-GENE-030131-5205

Name

mitochondrial rRNA methyltransferase 2

Symbol

mrm2 Nomenclature History

Previous Names

ftsj2 (1)
si:dkey-72a22.3
wu:fa18a02

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mrm2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial DNA depletion syndrome 17	Alliance	Mitochondrial DNA depletion syndrome 17	618567

Associated With mrm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002877	Ribosomal RNA methyltransferase, FtsJ domain
Family	IPR015507	Ribosomal RNA large subunit methyltransferase E
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily