Gene
src
- ID
- ZDB-GENE-030131-3809
- Name
- v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
- Symbol
- src Nomenclature History
- Previous Names
-
- fc54g04
- sb:cb864
- wu:fc54g04
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to localize to several cellular components, including extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in colon cancer; colorectal cancer; ductal carcinoma in situ; prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb864 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, advanced, somatic | 114500 |
| ?Thrombocytopenia 6 | 616937 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B2GS52
|
534 | ||||||||||
|
UniProtKB:A0A8M6YVT4
|
543 | ||||||||||
|
UniProtKB:Q1JPZ3
|
534 | ||||||||||
|
UniProtKB:A0A2R8QE56
|
540 | ||||||||||
|
UniProtKB:A0A8M6Z3N7
|
549 |
Interactions and Pathways
No data available
Plasmids
No data available