Gene

epha7

ID

ZDB-GENE-030131-3745

Name

eph receptor A7

Symbol

epha7 Nomenclature History

Previous Names

fc51g03
si:dkey-23k6.1
wu:fc51g03
zdk1 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane; neuron projection; and receptor complex. Is expressed in several structures, including forebrain midbrain boundary neural keel; forebrain midbrain boundary neural rod; hindbrain neural keel; mesoderm; and nervous system. Orthologous to human EPHA7 (EPH receptor A7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1096 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With epha7 Human Ortholog

No data available

Associated With epha7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001090	Ephrin receptor ligand binding domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR003961	Fibronectin type III
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR027936	Ephrin receptor, transmembrane domain
Domain	IPR034283	Ephrin type-A receptor 7, ligand binding domain
Family	IPR016257	Ephrin receptor type-A /type-B
Family	IPR050449	Ephrin receptor tyrosine kinases
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Ephrin receptor ligand binding domain	Ephrin receptor, transmembrane domain	Ephrin receptor type-A /type-B	Ephrin receptor tyrosine kinases	Ephrin type-A receptor 7, ligand binding domain	Fibronectin type III	Fibronectin type III superfamily	Galactose-binding-like domain superfamily	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin-like fold	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase ephrin type A/B receptor-like	Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A8M9PHF0 InterPro	990
UniProtKB:A0A8M9PST8 InterPro	1006
UniProtKB:A0A8M9PBU0 InterPro	1010
UniProtKB:A0A8M9PPF8 InterPro	998
UniProtKB:Q5VSJ4 InterPro	1016
UniProtKB:A0A8M9PHE5 InterPro	1006
UniProtKB:A0A8M9PSU2 InterPro	651
UniProtKB:A0A8M9P2N6 InterPro	994
UniProtKB:A0A8M9PBU2 InterPro	994