Gene

setdb1a

ID

ZDB-GENE-030131-2421

Name

SET domain bifurcated histone lysine methyltransferase 1a

Symbol

setdb1a Nomenclature History

Previous Names

fc07d03
si:ch211-81a5.6
wu:fc07d03

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have histone methyltransferase activity (H3-K9 specific) and promoter-specific chromatin binding activity. Predicted to be involved in Ras protein signal transduction; chromatin organization; and regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setdb1a Human Ortholog

No data available

Associated With setdb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR001739	Methyl-CpG DNA binding
Domain	IPR007728	Pre-SET domain
Domain	IPR040880	Domain of unknown function DUF5604
Domain	IPR041291	Histone methyltransferase, Tudor domain 1
Domain	IPR041292	Histone methyltransferase, Tudor domain 2
Domain	IPR047232	Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains
Homologous_superfamily	IPR016177	DNA-binding domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	DNA-binding domain superfamily	Domain of unknown function DUF5604	Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains	Histone methyltransferase, Tudor domain 1	Histone methyltransferase, Tudor domain 2	Methyl-CpG DNA binding	Pre-SET domain	SET domain	SET domain superfamily
UniProtKB:Q1L8U8 InterPro	1436

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	setdb1a-202 (1) Ensembl	Havana	4840 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	setdb1a-002 (1) Ensembl	Havana	493 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations