Gene
stag1b
- ID
- ZDB-GENE-030131-1393
- Name
- STAG1 cohesin complex component b
- Symbol
- stag1b Nomenclature History
- Previous Names
-
- fb69h03
- si:ch211-197k23.5
- wu:fb69h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromosome, centromeric region. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47. Orthologous to human STAG1 (STAG1 cohesin complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Ketharnathan et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ketharnathan et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nz205 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa14968 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24516 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24517 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37908 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37909 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 47 | Alliance | Intellectual developmental disorder, autosomal dominant 47 | 617635 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Cohesin subunit Scc3/SA | STAG | Stromalin conservative domain |
|---|---|---|---|---|---|
|
UniProtKB:E7FC33
|
1256 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stag1b-201
(1)
|
Ensembl | 4,970 nt | ||
| mRNA |
stag1b-202
(1)
|
Ensembl | 3,771 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197K23 | ZFIN Curated Data | |
| Encodes | EST | fb69h03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_687028 (1) | 4967 nt | ||
| Genomic | GenBank:CR376848 (1) | 218909 nt | ||
| Polypeptide | UniProtKB:E7FC33 (1) | 1256 aa |
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
- Kang, J.S., Bong, J., Choi, J.S., Henry, T.B., Park, J.W. (2016) Differentially transcriptional regulation on cell cycle pathway by silver nanoparticles from ionic silver in larval zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 479(4):753-758
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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